The present investigation was carried out during 2019 and 2020 on Wonderful pomegranate grown in sandy soil at new reclamation land in El-Minia Governorate. Three materials, Mega flowers (as a source of three growth regulators namely: NAA, NAD and β-NOA) at 250 ppm, 500 ppm and 750 ppm, mixture of three amino acids (glutamin, proline and Arginine) at 100 ppm and salicylic acid (SA) at 100 ppm were examined as foliar application. The obtained results during this study clearly explained the major role of spraying Mega flowers, amino acids and SA treatments in enhancing Wonderful pomegranate fruit quality. Where, it was found that spraying the three examined materials significantly improved the physic-chemical characteristics of fruit. It is worth to mention that, the combined application of the three materials (Mega flowers + amino acids + SA) showed remarkable and significant superiority over the individual application of each one alone. However, the trees received Mega flowers at 750 ppm + amino acid at 100 ppm + SA at 100 ppm produced the best fruit quality. Moreover, non-significant were observed between the two higher concentrations of Mega flowers. On the opposite side, untreated trees presented the lowest fruit physical and chemical properties, during the two experimental seasons.