Field examination spanning two years (2022-2023) have been done in the vine region of Minia Governorate, West of Samalout Center, to evaluated the effects of foliar application of different concentrations of macronutrients (NPK) and micronutrients (Zn, B, Fe), alone and in combination, on the yield and fruit quality of Flame Seedless grapevines. Treatments were applied thrice during the growing season, and results demonstrated that combined foliar sprays of macro and micronutrients significantly improved yield parameters such as berry set percentage, cluster number and weight, and overall yield per vine compared to untreated controls. The highest improvements in both yield and berry quality were achieved with the combined application of 1.0% NPK + 150 ppm Zn/B + 200 ppm Fe, followed closely by 0.75% NPK + 100 ppm Zn/B + 150 ppm Fe. These treatments also enhanced berry size, weight, chemical attributes including total soluble solids, TSS/TA, reducing sugars, and anthocyanin content and reduced shot berry percentage, as well as total acidity. The findings suggest that integrated foliar nutrient management optimizes both productivity and fruit quality in Flame Seedless grapevines under Minia field conditions.