Field examination spanning two years (2022-2023) have been done in the vine region of Minia Governorate, West of Samalout Center, to investigates the effects of foliar application of different concentrations of macronutrients (NPK) and micronutrients (Zn, B, Fe) on vegetative growth, leaf pigment content, and nutritional status of Flame Seedless grapevines. Treatments included various levels of NPK or micronutrients alone, and their combinations applied three times during the growing season. Results showed that combined foliar sprays of macro and micro -nutreints significantly enhanced shoot length, leaf number, leaf area, cane thickness, and pruning wood weight compared to untreated controls. Leaf chlorophyll and carotenoid as well as nutritional analysis contents were also highest in vines receiving combined macro- and micronutrients, indicating improved nutrient uptake and metabolic activity. The optimal treatment was foliar spraying with 0.75% NPK plus 100 ppm Zn/B and 150 ppm Fe, which maximized vegetative vigor and leaf pigment content while ensuring better economic returns for growers under local conditions. This integrated nutrient management approach supports sustainable viticulture by balancing growth and quality in Flame Seedless grapevines.